Welcome

I am Jacques Fattaccioli, Associate Professor in Chemistry at École Normale Supérieure (ENS-PSL), part of the MesoBioLab team within the CPCV Laboratory (Paris, France).

My work sits at the interface of microfluidics, soft matter, biophysics, and immunology, with a strong emphasis on droplet-based microfluidic systems. We design microfluidic platforms and surface/interface strategies to generate and functionalize droplets, control microscale environments, and build quantitative experiments that connect physico-chemical principles to biologically relevant questions.

Our group develops microfluidic platforms and engineered soft matter objects to address quantitative questions in biology, at scales ranging from single molecules to whole organisms.

A central research direction is the design of functional droplets and particles — lipid droplets engineered as artificial antigen-presenting cells, degradable microcapsules, and surface-functionalized microparticles — used as versatile tools to probe immune cell mechanics, phagocytosis, and receptor-ligand interactions with controlled interface chemistry.

We also develop microfluidic platforms for quantitative cell biology, combining hydrodynamic trapping arrays, droplet-based compartmentalization, and fluorescence microscopy to study single-cell dynamics, immune cell polarization, and intracellular processes at high throughput.

A third axis extends microfluidic approaches to plant and environmental biology: from the spatio-temporal study of moss development and microalgae phenotyping, to the dynamics of hydrocarbon-degrading bacterial biofilms at oil-water interfaces.

Feel free to contact us for any questions about our research, open positions, or potential collaborations.